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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Acta Neuropathol. 2017 Oct 20;135(1):33–47. doi: 10.1007/s00401-017-1772-0

Figure 1.

Figure 1.

Comparison of α-synuclein accumulation in oligodendroglial cells in the MBP-α-syn and in MSA. (a) α-synuclein accumulation (left panel) in oligodendroglial cells forming glial cytoplasmic inclusions (GCI’s). Luxol fast blue staining of myelin and oligodendrocytes in MSA brain (right panel). (b) Comparison of α-synuclein inclusions in the MBP model and MSA, images are from the white matter tracts in the striatum immunostained with antibodies against h-α-synuclein, misfolded α-synuclein (LB509 clone) and p-Ser129-α-synuclein. Bar=25 μm. (c) Schematic representation of the MBP transgenic mouse model of MSA driving human α-synuclein.