FIGURE 1.

Diagram of the interrelationships between the exposome (the totality of human environmental exposures, from conception onwards), genome (the genetic background of the individual), the endotype (biological networks that enable and restrict reactions) and the clinical phenotype (final clinical expression of the disease, e.g. symptoms, exacerbations, response to treatment, rate of disease progression or death). Reproduced from [6] with permission from the publisher.