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. Author manuscript; available in PMC: 2018 Sep 26.
Published in final edited form as: J Invest Dermatol. 2016 Jan 29;136(5):994–1001. doi: 10.1016/j.jid.2015.12.042

Figure 2. Naive CD45RA+CD4+ T cells inversely correlated with intratumoral cytotoxic T lymphocytes and were associated with shorter progression-free survival (PFS).

Figure 2.

(a) Flow cytometric analyses of blood leukocytes and tumor-infiltrated lymphocytes (TILs) assessing the lineage-related marker CD45RA in CD4+ T cells in a paired manner. (b, c) Spearman correlations between the percentages of CD4+CD45RA+ TILs and CD8+ cytotoxic T lymphocytes or PD1+CD8+ TILs. Each dot represents one patient. Wilcoxon paired signed-rank and Spearman correlation tests: P-values are indicated. (d) Kaplan-Meier PFS curves segregating the cohort of metastatic melanoma patients according to the median value of CD4+CD45RA+ TILs retained in the Cox multivariate model in tumor analyses. Likelihood ratio tests from Cox regression modeling are used to assess the prognostic value for the marker with and without accounting for metastatic lymph node (mLN) invasion status (0–3 vs >3).