Table 3:
Means of the estimates of parameters for the pharmacodynamic approach and their standard errors (in parentheses) from simulated data by mimicking the DICE data structure with different sample sizes based on 1000 simulation replicates (full genotypic model).
| Parameter | True Value | Sample Size |
||
|---|---|---|---|---|
| 100 | 200 | 400 | ||
| Emax1 | 9.934 | 10.511 (1.653) | 10.465 (1.417) | 10.332 (1.167) |
| H1 | 1.472 | 1.441 (0.589) | 1.435( 0.562) | 1.455 (0.517) |
| EC50(1) | 0.069 | 0.094 (0.089) | 0.082 (0.050) | 0.076 (0.024) |
| Emax2 | 17.637 | 17.317 (2.539) | 17.515 (2.228) | 17.668 (1.884) |
| H2 | 2.509 | 2.864 (0.796) | 2.723 (0.662) | 2.618 (0.477) |
| E50(2) | 0.551 | 0.544 (0.091) | 0.549 (0.068) | 0.552 (0.053) |
| Emax3 | 19.858 | 20.185 (2.422) | 20.060 (2.019) | 19.976 (1.567) |
| H3 | 2.2 | 2.580 (0.955) | 2.430 (0.779) | 2.340 (0.583) |
| EC50(3) | 0.13 | 0.144 (0.047) | 0.137 (0.028) | 0.134 (0.019) |
| α1 | −0.075 | −0.077 (0.086) | −0.074 (0.058) | −0.074 (0.040) |
| α2 | 0.113 | 0.116 (0.109) | 0.111 (0.072) | 0.112 (0.050) |
| v11 | 2.135 | 2.178 (1.100) | 2.150 (0.775) | 2.117 (0.527) |
| v12 | −1.065 | −1.074 (1.407) | −1.104 (0.966) | −1.104 (0.681) |
| v13 | −3.553 | −3.531 (1.427) | −3.532 (0.944) | −3.521 (0.668) |
| v14 | 3.037 | 2.978 (1.641) | 3.014 (1.124) | 3.039 (0.822) |
| v21 | 3.855 | 3.943 (1.666) | 3.925 (0.956) | 3.872 (0.627) |
| v22 | −6.059 | −6.031 (2.081) | −6.039(1.279) | −6.044 (0.874) |
| v23 | 4.904 | 5.001 (2.418) | 4.943 (1.417) | 4.902 (0.998) |
| v31 | −0.798 | −0.829 (0.699) | −0.814 (0.464) | −0.816 (0.322) |
| ρ | 0.754 | 0.738 (0.027) | 0.746 (0.020) | 0.750 (0.014) |
| σ2 | 71.401 | 66.294 (6.071) | 68.769 (4.415) | 69.995 (3.103) |
Note: α1 and α2 are the effects due to two continuous covariates; v1, v2 and v3 are the effects due to three discrete covariates each with a different level; and ρ and σ2 are the autoregressive parameters that model the covariance structure.