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. 2018 Sep 14;194(1):54–66. doi: 10.1111/cei.13185

Figure 5.

Figure 5

Effective induction of cytomegalovirus (CMV)pp65‐specific CD8+ T cells by healthy donor (HD)‐derived interferon dendritic dells/peptide and zoledronate plus α‐galactosylceramide (IFN DCs/P+Z+G). (a) The ability of IFN DCs from human leucocyte antigen (HLA)‐A*0201‐positive HD‐1 pulsed with HLA‐A*0201‐restricted P and Z+G to induce CMV‐specific CD8+ T cells was higher than that of IFN DCs/P. Using IFN DCs/P+Z+G, the expansions of Vγ9γδT and Vα24NKT cells were also observed. (b) The ability of IFN DCs from HLA‐A*0201‐positive HD2 pulsed with HLA‐A*0201‐restricted P+Z+G to induce CMV‐specific CD8+ T cells was higher than that of IFN DCs/P. Using IFN DCs/P+Z+G, expansions of Vγ9γδT and Vα24NKT cells were also observed. (c) The percentage of CD4+CD25+forkhead box protein 3 (FoxP3)+regulatory T cells (Tregs) among lymphocytes from three HLA‐A*0201‐positive HDs (HD‐1, H‐2 and HD‐3) following co‐culture with autologous IFN DCs pulsed with HLA‐A*0201‐restricted P+Z+G) was lower than that following co‐culture with autologous IFN DCs/P.