Table 2.
Correlation of trauma patient complement levels, thrombin generation and inhibition of polymorphonuclear leucocytes (PMN) extracellular reactive oxygen species (ROS) production by complement component 5a receptor (C5aR) antagonism
| ΔExtracellular ROS | C5a level | C4d level | Bb level | PF1+2 level | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| r | P‐value | r | P‐value | r | P‐value | r | P‐value | r | P‐value | |
| ΔExtracellular ROS | 0·309 | 0·027 | 0·033 | 0·815 | 0·464 | < 0·001 | 0·371 | 0·006 | ||
| C5a level | 0·309 | 0·027 | 0·198 | 0·254 | 0·626 | < 0·001 | 0·350 | 0·039 | ||
| C4d level | 0·033 | 0·815 | 0·198 | 0·254 | 0·185 | 0·278 | 0·063 | 0·714 | ||
| Bb level | 0·464 | < 0·001 | 0·626 | < 0·001 | 0·185 | 0·278 | 0·271 | 0·109 | ||
| PF1+2 level | 0·371 | 0·006 | 0·350 | 0·039 | 0·063 | 0·714 | 0·271 | 0·109 | ||
PF1+2 = prothrombin fragment 1+2.