Table 1.
Estimates of regression coefficients for methylation, fenofibrate, and methylation-fenofibrate interactions, with and without adjusting for HDL using the whole samplea
| With adjustment for HDL | Without adjustment for HDL | |||||||
|---|---|---|---|---|---|---|---|---|
| Chr | Gene | CpG | Methylation (p) | Treatment (p) | Interaction (p) | Methylation (p) | Treatment (p) | Interaction (p) |
| 1 | ZNF692 | cg02899039 | −0.16 (0.21) | −0.48 (1.11 × 10 −60 ) | 1.13 (8.14 × 10 −8 ) | 0.24 (9.22 × 10− 2) | −0.35 (1.25 × 10− 38) | 0.35 (2.27 × 10− 2) |
| 1 | HS2ST1 | cg07212563 | 0.56 (0.13) | 0.83 (0.13) | −1.36 (4.34 × 10−2) | 0.72 (4.24 × 10− 2) | 2.28 (2.80×10 − 7 ) | −2.84 (3.91 × 10 − 9 ) |
| 1 | ZNF692 | cg11817309 | − 0.02 (0.45) | − 0.44 (1.90 × 10 −71 ) | 1.24 (1.24 × 10 − 14 ) | 0.51 (2.03 × 10− 5) | −0.34 (1.38 × 10− 47) | 0.35 (2.00 × 10− 2) |
| 3 | SPSB4 | cg20354777 | 0.48 (0.09) | 1.77 (7.07 × 10 −7 ) | − 2.68 (1.58 × 10 − 9 ) | 0.62 (1.94 × 10− 2) | 1.56 (6.09 × 10 − 7 ) | − 2.32 (2.38 × 10 − 9 ) |
| 5 | SDHA | cg00089430 | 1.49 (0.02) | 2.92 (3.42 × 10 − 6 ) | − 3.81 (1.22 × 10 − 7 ) | 1.07(3.52 × 10− 2) | 2.20 (4.26 × 10− 4) | − 2.89 (6.20 × 10− 5) |
| 8 | PBK | cg17795291 | 0.28 (0.17) | 0.34 (0.34) | −0.85 (0.17) | 0.45 (3.63 × 10− 2) | 3.25 (5.91 × 10 − 7 ) | −3.99 (3.70 × 10 − 8 ) |
| 9 | BRD3 | cg13773148 | 1.42 (6.49 × 10−3) | 3.79 (9.84 × 10− 4) | −4.60 (2.88 × 10− 4) | 1.40 (4.00 × 10− 3) | 5.19 (4.00 × 10 − 7 ) | − 6.04 (7.05 × 10 − 8 ) |
| 13 | MIPEP | cg14710025 | −1.64 × 10− 2 (0.48) | 0.89 (0.14) | − 1.48 (5.91 × 10− 2) | 0.36 (12.74 × 10− 2) | 2.54 (2.65 × 10 − 6 ) | − 3.26 (1.28 × 10 − 7 ) |
| 16 | C16orf13 | cg16757281 | −3.24 (5.66 × 10 −5 ) | −0.79 (7.07 × 10 − 26 ) | 6.75 (4.96 × 10 − 9 ) | − 2.90 (7.98 × 10− 5) | −0.63 (2.59 × 10− 14) | 5.20 (1.11 × 10− 5) |
| 19 | TNFSF14 | cg23071186 | −0.93 (7.90 × 10 −5 ) | − 0.76 (3.87 × 10 − 27 ) | 1.42 (5.53 × 10 − 8 ) | −0.79 (2.18 × 10− 4) | −0.600 (1.75 × 10− 22) | 1.09 (1.12 × 10− 6) |
| 21 | ABCC13 | cg04985582 | −0.35 (3.28 × 10−3) | − 0.75 (< 10− 20) | 0.57 (2.80 × 10− 6) | − 0.31 (2.20 × 10− 3) | −0.69 (< 10 − 20 ) | 0.61 (3.90 × 10 − 9 ) |
aTable shows only CpGs with a p value for the interaction ≤1.43 × 10− 7 on log-transformed TG, adjusted for age, sex, study site, and smoking. The numbers in boldface refers to estimates and p values for the main and interaction effects where significant methylation-fenofibrate interactions were observed. A total of 421 individuals from 138 families with both pre- and posttreatment data were included in these analyses