Fig. 2.

Snail binds directly to the TEL2 promoter in NPC cells. a Schematic illustration of the wild-type TEL2 promoter and its mutants in luciferase reporter assays. b, c S26 cells stably transfected with empty vector or Snail-encoding plasmid were transfected with a luciferase reporter plasmid in which luciferase expression was driven by the wild-type or mutant TEL2 promoter. Luciferase activity was measured as described in Methods. Data are mean ± SEM of triplicate samples. *P < 0.05, **P < 0.01. d Schematic illustration of the location of primers for ChIP analysis. e–g Cells were analyzed in ChIP assays using anti-Snail antibody as described in “Methods”