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. 2018 Sep 25;38:58. doi: 10.1186/s40880-018-0328-6

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Snail promotes NPC metastasis to lung mostly by down-regulating TEL2 in a nude mouse model. a–c Stably transfected cells were injected into the lateral tail vein of nude mice. a Quantitation of the number of metastases. Data are mean ± SEM (n = 6 per group). b Macroscopic appearance of metastatic lung tumors. c Tumor cross sections with hemotoxylin-eosin staining. Scale bars in (c): 500 μm (left), 50 μm (right). d Proposed model for the regulation and function of TEL2 in NPC metastasis. Snail down-regulates TEL2 during exposure to normoxia or hypoxia, up-regulating SERPINE1, which promotes NPC metastasis