Table 3.
Enrichment analysis showing 20 most overrepresented1 Biological Process for differentially expressed genes2 for diet and biologically relevant contrasts in the blood tissue
| Biological Process | # genes | FE | P-value |
|---|---|---|---|
| Diet | |||
| Regulation of carbohydrate metabolic process (GO:0006109) | 3 | 6.54 | 1.37E-02 |
| Translation (GO:0006412) | 22 | 4.3 | 3.42E-08 |
| Glycogen metabolic process (GO:0005977) | 3 | 4.03 | 4.38E-02 |
| Transcription initiation from RNA polymerase II promoter (GO:0006367) | 4 | 3.81 | 2.47E-02 |
| rRNA metabolic process (GO:0016072) | 10 | 3.77 | 5.20E-04 |
| Protein targeting (GO:0006605) | 8 | 2.3 | 2.73E-02 |
| Cellular component biogenesis (GO:0044085) | 36 | 2.08 | 6.01E-05 |
| Protein localization (GO:0008104) | 18 | 1.72 | 2.71E-02 |
| Organelle organization (GO:0006996) | 39 | 1.51 | 1.36E-02 |
| Biosynthetic process (GO:0009058) | 55 | 1.49 | 4.07E-03 |
| Cellular component organization or biogenesis (GO:0071840) | 65 | 1.48 | 1.68E-03 |
| Cellular component organization (GO:0016043) | 54 | 1.32 | 3.77E-02 |
| Primary metabolic process (GO:0044238) | 119 | 1.19 | 3.26E-02 |
| Weaning | |||
| Translation (GO:0006412) | 101 | 5.84 | 6.58E-42 |
| Peptide biosynthetic process (GO:0043043) | 101 | 5.64 | 8.81E-41 |
| Amide biosynthetic process (GO:0043604) | 103 | 5.09 | 3.67E-38 |
| Peptide metabolic process (GO:0006518) | 103 | 4.8 | 3.40E-36 |
| Cellular amide metabolic process (GO:0043603) | 106 | 4.08 | 7.70E-32 |
| Ribosome biogenesis (GO:0042254) | 37 | 3.65 | 1.55E-10 |
| Organonitrogen compound biosynthetic process (GO:1901566) | 125 | 2.68 | 4.22E-22 |
| Cellular macromolecule biosynthetic process (GO:0034645) | 181 | 2.21 | 4.73E-23 |
| Macromolecule biosynthetic process (GO:0009059) | 181 | 2.17 | 1.99E-22 |
| Cellular nitrogen compound biosynthetic process (GO:0044271) | 165 | 2.11 | 4.11E-19 |
| Gene expression (GO:0010467) | 168 | 1.85 | 3.42E-14 |
| Cellular protein metabolic process (GO:0044267) | 213 | 1.84 | 3.63E-18 |
| Organic substance biosynthetic process (GO:1901576) | 203 | 1.8 | 2.37E-16 |
| Cellular biosynthetic process (GO:0044249) | 198 | 1.8 | 9.94E-16 |
| Biosynthetic process (GO:0009058) | 204 | 1.76 | 1.74E-15 |
| Organelle organization (GO:0006996) | 178 | 1.74 | 6.55E-13 |
| Cellular nitrogen compound metabolic process (GO:0034641) | 232 | 1.7 | 3.41E-16 |
| Protein metabolic process (GO:0019538) | 232 | 1.64 | 1.84E-14 |
| Cellular macromolecule metabolic process (GO:0044260) | 293 | 1.62 | 1.85E-18 |
| Cellular component organization or biogenesis (GO:0071840) | 252 | 1.52 | 2.74E-12 |
| Macromolecule metabolic process (GO:0043170) | 320 | 1.42 | 2.33E-12 |
| Vaccination | |||
| Myeloid leukocyte activation (GO:0002274) | 8 | 5.47 | 1.93E-04 |
| Transition metal ion transport (GO:0000041) | 9 | 5.07 | 1.32E-04 |
| Positive regulation of response to external stimulus (GO:0032103) | 14 | 3.22 | 2.06E-04 |
| Positive regulation of GTPase activity (GO:0043547) | 22 | 3.18 | 4.20E-06 |
| Regulation of GTPase activity (GO:0043087) | 23 | 2.87 | 1.27E-05 |
| Positive regulation of hydrolase activity (GO:0051345) | 28 | 2.4 | 3.93E-05 |
| Regulation of response to external stimulus (GO:0032101) | 26 | 2.35 | 9.76E-05 |
| Cellular homeostasis (GO:0019725) | 28 | 2.24 | 1.36E-04 |
| Immune system process (GO:0002376) | 58 | 1.93 | 2.65E-06 |
| Regulation of hydrolase activity (GO:0051336) | 40 | 1.92 | 1.71E-04 |
| Positive regulation of response to stimulus (GO:0048584) | 56 | 1.78 | 3.82E-05 |
| Cellular response to organic substance (GO:0071310) | 55 | 1.77 | 5.19E-05 |
| Cellular response to chemical stimulus (GO:0070887) | 67 | 1.75 | 1.25E-05 |
| Localization (GO:0051179) | 141 | 1.61 | 3.46E-09 |
| Establishment of localization (GO:0051234) | 110 | 1.6 | 6.83E-07 |
| Transport (GO:0006810) | 104 | 1.57 | 3.50E-06 |
| Regulation of response to stimulus (GO:0048583) | 97 | 1.54 | 2.14E-05 |
| Cell differentiation (GO:0030154) | 84 | 1.53 | 8.59E-05 |
| Regulation of signal transduction (GO:0009966) | 77 | 1.53 | 2.22E-04 |
| Regulation of signaling (GO:0023051) | 83 | 1.5 | 2.22E-04 |
| Developmental process (GO:0032502) | 118 | 1.39 | 1.65E-04 |
1P-value < 0.05;
2q-value < 0.05;
FE = fold enrichment