Figure 2. Senescence markers associated with long and short isografts.

At an early 4 week endpoint, long isografts had an impact on SAβ-gal activity in the nerve proximal to the graft and as well as in the graft (A). Gene expression for senescence markers, p16 and p21 (B), were elevated compared to normal nerve but not different between grafts at 4 weeks. However, by 8 weeks, regions of the long graft had elevated p16 and p21 expression compared to the short graft. * p<0.05, n=4-6 per group.