TABLE 2.

CALCULATION OF NUMBER DSBS PER MEIOSIS. RELATED TO FIGURES 1 AND 2.

WILD-TYPE DSB CALCULATION
WILD-TYPE STOCKS SEQUENCED		196
NCOGCS (EXPECTED)
NCOGC RATE1 (CALCULATED)		2.10E-08
NCOGCS PER HAPLOID MEIOSIS		2.8
DSBS THIS ACCOUNTS FOR PER MEIOSIS		11.1
COS (OBSERVED)
TOTAL COS OBSERVED		541
DOUBLE CO NUMBER AS ONLY 1/2 ARE OBSERVED		1082
BREAKS PER STOCK ON THE X		5.5
TOTAL BREAKS		16.6
DSB CALCULATION USING DATA FROM THE X AND NCOGC RATE FROM BALANCERS
CYO; TM6B STOCKS SEQUENCED	50
CYO AND TM6B EVENTS (OBSERVED AND EXPECTED)
NCOGC RATE1 (CALCULATED)	2.95E-08
2ND AND 3RD CHROMOSOME NCOGCS PER HAPLOID MEIOSIS	3.2
DSBS THIS ACCOUNTS FOR PER MEIOSIS	12.9
CHROMOSOME X EVENTS (OBSERVED AND EXPECTED)
TOTAL COS OBSERVED	70
DOUBLE CO NUMBER AS ONLY 1/2 ARE OBSERVED	140
NCOGC RATE (CALCULATED)	1.86E-08
X CHROMOSOME NCOGCS PER HAPLOID MEIOSIS	0.44
BREAKS NCOGCS ACCOUNT FOR IN ALL STOCKS	88
TOTAL BREAKS ON THE X	228
BREAKS PER STOCK ON THE X	4.6
TOTAL BREAKS	17.5

¹NCOGC rates are maximum likelihood estimates. See Methods for description.