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. Author manuscript; available in PMC: 2019 Sep 25.
Published in final edited form as: ACS Nano. 2018 Sep 14;12(9):9342–9354. doi: 10.1021/acsnano.8b04348

Figure 10. Analysis of LSPR shifts upon simultaneous variation of biomarker concentration in human tears.

Figure 10.

Gaussian fits to LSPR peaks of AuNS@PNM normalized extinction spectra and quantitative analysis of shifts in LSPR of AuNS@PNM with increasing concentrations of both lysozyme (Lys) and lactoferrin (Lf) in either PBS or HBS. For clarity, Gaussian fits for high concentrations (i.e., >96 μg/mL) were omitted. The shifts in LSPR in PBS (a-b) were smaller and showed a larger dynamic response across the concentrations tested compared to shifts observed in HBS (c-d). LSPR shifts which correspond to those of dry eye (DE) are represented by the red region, those which are borderline/additional testing recommended are represented by the orange region, and those which would be classified as non-dry eye (NDE) are represented by the yellow region (b,d). Data are reported as mean ± SD (n≥3).