Table 3.
Association of markers of mass effect with outcome.
| Spearmans p | ROC (for mRS 3–6 at day 90) | ROC (for mortality at day 90) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| AUC | Criterion value | Sensitivity | Specificity | AUC | Criterion value | Sensitivity | Specificity | ||
| DWI lesion volume BL [ml] | 0.455** | 0.716 | 27.3 | 79.3% | 57.1% | 0.482 | 90.6 | 88.1% | 33.3% |
| Swelling volume [ml] | 0.597** | 0.791 | 10.4 | 79.3% | 73.8% | 0.661 | 3.4 | 30.5% | 100.0% |
| Midline shift [mm] | -- | 0.682 | 2.00 | 79.3% | 52.4% | 0.662 | 3.2 | 88.1% | 50.0% |
| Change in ipsilateral hemisphere volume BL to FU [%] | 0.486** | 0.700 | 3.6 | 75.9% | 61.9% | 0.688 | 9.8 | 91.5% | 41.7% |
| Ratio hemisphere volumes FU | 0.612** | 0.753 | 1.06 | 65.5% | 76.2% | 0.645 | 1.14 | 81.4% | 58.3% |
| Change in ipsilateral ventricle volume BL to FU [%] | −0.561** | 0.583 | −18.4 | 54.8% | 69.0% | 0.541 | −61.8 | 100.0% | 16.7% |
| Ratio lateral ventricle volumes FU | −0.589** | 0.645 | 0.98 | 88.1% | 34.5% | 0.571 | 0.54 | 93.2% | 33.3% |
Spearmans p is shown for correlation with midline shift. AUC = area under the curve; ROC = receiver operating characteristics; mRS = modified Rankin Scale; BL = baseline; FU = follow-up.
**
p = <0.0001,
*
p <0.01