Two-phase gastric emptying does not contribute to diabetic
gastroparesis. A) The proportion of gastric emptying tests better fit by the
GVS2 model (light gray; 2 peak) than the GVS model (dark gray; 1 peak) were not
different in NOD/ShiLtJ mice that remained non-diabetic, were diabetic and had
normal gastric emptying (resistant), or were diabetic and exhibited delayed
gastric emptying (P>0.05, Chi-Square). B) In B6;C3Fe
a/a-Csf1<+> treated with streptozotocin (STZ), there was a
greater proportion of gastric emptying tests better fit by the GVS2 model (light
gray; 2 peak) than the GVS model (dark gray; 1 peak) in delayed versus resistant
mice (*P<0.05, Fishers Exact Test). Representative data from individual
gastric emptying experiments that were better fit with the GVS model (C and D)
or GVS2 model (E and F) for STZ-treated B6;C3Fe a/a-Csf1<+> mice
with normal (C and E) or delayed (D and F) gastric emptying illustrates the
similarities between 1-peak and 2-peak curves for delayed versus resistant
mice.