Table 1.
Body composition, absolute and relative heart weight
| SD n = 7 | FFC n = 14 | FFC/SD n = 14 | Overall P value | |
|---|---|---|---|---|
| BW (kg) | ||||
| Mid-study | 31.0 (30.0–32.0) | 50.0 (47.0–55.0)*** | 49.5 (47.0–54.0)*** | 0.0003 |
| Termination | 39.0 (38.0–41.0) | 78.0 (69.0–81.0)*** | 55.0 (51.0–59.0)***†††† | <.0001 |
| Fat percentage (%) | ||||
| Mid-study | 20.5 (18.5–26.3) | 40.2 (37.6–41.9)*** | 41.6 (38.8–44.5)*** | 0.0001 |
| Termination | 27.6 (24.0–30.7) | 64.2 (61.4–67.6)*** | 47.3 (41.2–50.2)***†††† | <.0001 |
| LBM (kg) | ||||
| Mid-study | 22.8 (20.1–23.1) | 27.1 (25.0–28.2)** | 25.6 (24.4–26.3)** | 0.002 |
| Termination | 26.9 (24.0–28.6) | 27.0 (24.8–27.8) | 29.5 (27.3–30.5) | 0.2 |
| HW (g) | ||||
| Termination | 131 (115–142) | 199 (181–208)a*** | 173 (168–180)*** | <.0001 |
| HW/BW (g/kg) | ||||
| Termination | 3.3 (3.1–3.4) | 2.6 (2.5–2.8)a*** | 3.3 (3.0–3.4)†††† | <.0001 |
| HW/LBM (g/kg) | ||||
| Termination | 5.0 (4.2–5.2) | 7.7 (6.8–8.2)a*** | 6.2 (5.9–6.7)***††† | <.0001 |
Data is presented as median and interquartile range (25th–75th)
SD fed standard chow, FFC fed fat/fructose/cholesterol-rich diet, FFC/SD dietary normalization, BW body weight, LBM lean body mass, HW heart weight
**P < 0.01; ***P < 0.001, significantly different from SD, †††P < 0.001; ††††P < 0.0001, significantly different from FFC
a n = 13