Fig. 7.

Comparing VT/SIDES/INFO+ for models that simulate successful trials, where there is a treatment effect on the outcome independently of the covariates. This is the average TPR over 200 simulated datasets for various values of the predictive strength θ: small values of θ mean that the prognostic signal is stronger than the predictive, while the opposite holds for large values of θ. For θ = 1 both signals have the same strength. The sample size is 2000 and the dimensionality p = 30 biomarkers. (a) M-8: Common treatment effect. (b) M-9: Stochastic subject-specific treatment effect