Table 2.

MR results with CIV and TSLS at RNMT;C18orf19 and C6orf141 using the SNP sets F and R

Gene	# SNPs selected by CIV	Instrument strength of CIV: F-stat/CP a	Instrument strength of TSLS: F-stat/CP a	#Associated probes by CIV b (# also naïve)	#Associated probes by TSLS c (# also naïve)
RNMT;C18orf19	1	22.83/22.96	(F) 2.21/346.03 (R) 8.88/136.39	1(1)	1(1)
C6orf141	11	1.42/27.81	(F) 1.35/78.01 (R) 1.12/23.01	3(1)	1(1)

The number of associated probes based on 95% bootstrap confidence intervals is shown, and the instrument strength at the most strongly associated CpG is also reported. Egger regression with SNP set F only identified the probe in C6orf141.

^a F-stat/CP,F-statistic/concentration parameter

^b Number of CpGs showing significant MR association with CIV (number of these probes also demonstrating naïve association)

^c TSLS has the same result using set F or set R