Table 4.
Subcutaneous and IV Ig products carried by Canadian Blood Services [33]
| Brand name | GAMUNEX® | IGIVnex® | Hizentra™ | Cuvitru™ |
|---|---|---|---|---|
| Subcutaneous Ig | ||||
| Indications | PID, SID | PID, SID | PID, SID | |
| Concentration | 10% | 20% solution (200 mg/mL) | 20% | |
| IgA content | Average 0.046 g/L | No more than 50 mg/L (avg 8 mg/L) | Average < 80 mcg/mL; no more than 280 mcg/mL | |
| Storage temperature | May be stored for 36 months at + 2 to + 8 °C, and product may be stored at temperatures not to exceed 25 °C (77°F) for up to 6 months anytime during the 36 month shelf life | + 2 to + 25 °C can be stored either in the refrigerator or at room temperature | + 2 to + 8 °C | |
| Recommeneded infusion rate | 20 mL/hr per infusion site | 15 mL/h per site Subsequent infusions, maximum of 34 mL per hour per site as tolerated | ≤ 60 mL/hr/site up to 4 sites | |
| Availabe sizes distributed by CBS | 2.5 g/25 mL, 5 g/50 mL, 10 g/100 mL, 20 g/200 mL | 20g/200 mL | 5, 10, 20, 50 mL | 1 g/5 mL, 2 g/10 mL, 4 g/20 mL, 8 g/40 mL |
| Manufacturer website | http://www.grifols.com | http://www.cslbehring.ca | https://www.shirecanada.com | |
| Brand name | Gammagard S/D | GAMUNEX® | IGIVnex® | Gammagard Liquid | Privigen® | Octagam® 10% |
|---|---|---|---|---|---|---|
| IV Ig | ||||||
| Indications | PID CLL ITP |
PID, ITP, SID, CIDP in adults ≥ 18 years of age | PID, SID, ITP, MMN | PID, SID, ITP, CIDP | ITP patients at high risk of bleeding or prior to surgery to correct platelet count | |
| Concentration | 5 or 10% upon reconstitution | 10% | 10% | 10% | 10% | |
| IgA content | ≤ 2.2 μg/mL in 5% solution | Average 0.046 g/L | ≤ 0.14 mg per mL | No more than 25 mcg/mL | < 0.4 mg/mL | |
| Storage temparature | Not to exceed +25 °C (77F) | May be stored for 36 months at +2 to +8 °C, AND product may be stored at temperatures not to exceed +25 °C (77°F) for up to 6 months anytime during the 36 month shelf life | Store in refrigerator (+ 2 to + 8 °C) for up to 36 months. Within the first 24 months of the date of manufacture, product may be stored for a single period of up to 12 months at room temperature (below + 25 °C). After this period, unused product must be discarded. |
Can be stored either in the refrigerator or at room temperature + 2 to + 25 °C | Store at + 2 to + 8 °C for 23 months from the date of manufacture. Within this shelf-life, product may be stored up to 3 months at ≤ 25 °C. After the storage at ≤ 25 °C the product must be used or discarded | |
| Initial recommended infusion rate | 5 or 10% solution: 0.5 mL/kg/h | 0.01 to 0 02 mL/kg per min (1 to 2 mg/kg per min) for the first 30 min | 0.5 mL/kg BW/hr for 30 min For MMN: 0.5 mL/kg BW/hr |
0.5 mg/kg/min (0.3 mL/kg/hr) | 1 mg/kg/min (0.01 mL/kg/min) for the first 30 min | |
| Availabe sizes distributed by CBS | 5 g/vial | 2.5 g/25 mL, 5 g/50 mL, 10 g/100 mL, 20 g, 200 mL | 20 g/200 mL | 2.5 g/25 mL, 5 g/50 mL, 10 g/100 mL, 20 g/200 mL, 30 g/300 mL | 2.5 g/25 mL, 5 g/50 mL, 10 g/100 mL, 20 g/200 mL, 40 g/400 mL | 5 g/50 mL, 10 g/100 mL, 20 g/200 mL |
| Manufacturer website | http://www.baxter.ca | http://www.grifols.com | http://www.baxter.ca | http://www.cslbehring.ca | www.octapharma.ca | |
Adapted from Canadian Blood Services 2016. Complete tables available at: https://professionaleducation.blood.ca/en/transfusion/clinical-guide/immune-globulin-products
These products may not be available in all cities/provinces across Canada, and other Ig products not listed here may be available
PID primary immunodeficiency, SID secondary immunodeficiency, ITP idiopathic thrombocytopenic purpura, CIDP chronic inflammatory demyelinating polyneuropathy, CLL B-cell chronic lymphocytic leukemia, MMN multifocal motor neuropathy, BW body weight