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. 2018 Sep 19;9:2132. doi: 10.3389/fimmu.2018.02132

Figure 4.

Figure 4

IL-33 is critical for the enhanced inflammation and the protection against Nippostrongylus brasiliensis infection. WT and Il33−/− mice (n = 3) were infected with S. venezuelensis (Sv) at day 0. (A) BALF cells from uninfected (day 0) or S. venezuelensis-infected mice at the indicated days were analyzed as in Figure 1H. Data are representative of two independent experiments that had similar results. (B) Il5 and Il13 mRNA expression levels in the lungs were examined. (C–E) WT and Il33−/− mice were infected with N. brasiliensis 4 weeks after S. venezuelensis (Sv) infection. S. venezuelensis-uninfected mice were used as a control (cont). Five days after N. brasiliensis infection, the number of ILC2s and eosinophils (n = 10–12) (C) and the Il5 and Il13 mRNA expression levels (n = 5–7) in the lungs were examined (D). (E) The numbers of worms in the intestine were counted (n = 10–12). Pooled data from (C,E) or representative of (D) two independent experiments are shown (Mean ± SD).