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. 2018 Sep 19;9:1314. doi: 10.3389/fphys.2018.01314

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Copyright © 2018 Svandova, Vesela, Lesot, Sadoine, Poliard and Matalova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of prenatal (E15) jaw bone of gld mice. The mandibular bone visualized by trichrome staining in gld mouse (A) and wild-type mice (B), decrease of bone matrix in gld mice (n = 3 animals) compared to wild-type animals (n = 3 animals), avg_gld = 184.125 μm², sd_gld = 35.484, avg_wt = 296.026 μm², sd_wt = 53.478, p = 0.0392 (C₁,C₂), decrease of osteoclasts detected by TRAP-staining in gld mice (n = 3 animals) compared to wild-type mice (n = 3 animals), avg_gld = 159, sd_gld = 14, avg_wt = 296, sd_wt = 47, p = 0.0079 (D₁,D₂), TRAP-staining in gld (E) and wild-type mice (F) detection of apoptotic cells (TUNEL) in the mandibular bone of gld (G) and wild-type mice (H). Arrows point to the positive cells (immunohistochemistry-brown, TRAP-purple). Scale bar = 100 μm. ^∗p ≤ 0.05 and ^∗∗p ≤ 0.01.