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. 2018 Sep 19;9:1314. doi: 10.3389/fphys.2018.01314

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Copyright © 2018 Svandova, Vesela, Lesot, Sadoine, Poliard and Matalova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of postnatal (P24) jaw bone of gld mice. Increased mineralization in gld (A) compared to wild-type mouse (B) where bright color shows increased mineralization, frontal section of the mandible of gld (C) and wild-type mice (D), increased BV/TV ratio in gld mice (n = 6 animals) compared to wild-type mice (n = 6 animals), avg_gld = 0.3763 mm³, sd_gld = 0.0301 vs. avg_wt = 0.2978 mm³, sd_wt = 0.0268, p = 0.0008, Student’s t-test, two-tailed (E), increased Trab.Th in gld mice (n = 6 animals) compared to wild-type mice (n = 6 animals), avg_gld = 0.1020 mm, sd_gld = 0.0046 vs. avg_wt = 0.0896 mm, sd_wt = 0.0043, p = 0.0007, Student’s t-test, two-tailed (F), increased Trab.N in gld mice (n = 6 animals) compared to wild-type mice (n = 6 animals), avg_gld = 3.6872 1/mm, sd_gld = 0.1874 vs. avg_wt = 3.3277 1/mm, sd_wt = 0.2954, p = 0.0152, Mann–Whitney test (G), decreased Trab.Pf in gld mice (n = 6 animals) compared to wild-type mice (n = 6 animals), avg_gld = 6.0641 1/mm, sd_gld = 1.0851 vs. avg_wt = 8.1548 1/mm, sd_wt = 1.5312, p = 0.0087, Mann–Whitney test (H). ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, and ^∗∗∗p ≤ 0.001.