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. 2018 Sep 18;9:2183. doi: 10.3389/fmicb.2018.02183

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Copyright © 2018 Bhatt, Mohapatra, Anand, Kuntal and Mande.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Representation of the evolutionarily conserved Man gene cluster and its corresponding enzymes involved in the conversion of Mannose to GDP-Fucose in Escherichia coli and Bacteroides thetaiotaomicron. (B) Reorganization of the genes within the Pathway into functionally relevant modules (GCMs) by considering gene context information. The GCM ‘D-Mannose to GDP-L-Fucose’ was present in E. coli and its corresponding pfams for the chosen cut-off and window size are highlighted in (C). (D) Absence of the module in B. thetaiotaomicron.