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. 2018 Sep 18;28(10):1243–1251. doi: 10.1089/thy.2018.0116

FIG. 2.

FIG. 2.

Comparison of timeline of thyroiditis with nivolumab versus combination of ipilimumab + nivolumab. The time to thyrotoxicosis with nivolumab was six weeks [confidence interval (CI) 3.6–8.4] versus two weeks [CI 1.19–2.8] with the combination of ipilimumab + nivolumab (p = 0.26). The time to hypothyroidism from the start of ICI was 10 weeks with the combination of ipilimumab and nivolumab [CI 8.1–11.9] versus 17 weeks [CI 8.82–25.18] with nivolumab alone (p = 0.029). Two patients on ipilimumab and nivolumab died prior to developing hypothyroidism.