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. 2018 Sep 18;28(10):1243–1251. doi: 10.1089/thy.2018.0116

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Copyright 2018, Mary Ann Liebert, Inc., publishers

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FIG. 3. — Proposed algorithm for management of immune checkpoint inhibitor (ICI)-mediated thyroiditis. The figure below outlines a proposed algorithm for evaluation in patient on ICI therapy in whom thyroiditis is suspected. Common Terminology Criteria for Adverse Events (CTCAE) v.4 criteria: grade 1—asymptomatic; clinical or diagnostic observations only; intervention not indicated; grade 2—symptomatic; thyroid suppression therapy indicated; limiting instrumental activities of daily living (ADL); grade 3: severe symptoms limiting self-care ADL and hospitalization indicated; grade 4—life-threatening consequences; urgent intervention indicated; grade 5: death.