Table 1.

Correlation between different clinical variables reflecting HFRS disease severity and markers of neutrophil activation.

		Creatinine (max)	Platelets (min)	Leukocyte count (max)	tPA	MPO	HNE	Histones	IL-8
MPO	r	0.215	−0.582**	0.405**	0.571*	1.000	0.363**	0.329*	0.659**
	Sig.	0.123	0.000	0.003	0.021		0.008	0.016	0.000
	n	53	52	52	16	53	53	53	36
HNE	r	0.364**	−0.420**	0.296*	0.636**	0.363**	1.000	0.130	0.474**
	Sig.	0.007	0.002	0.033	0.008	0.008		0.352	0.004
	n	53	52	52	16	53	53	53	36
Histones	r	0.228*	−0.260	0.273	−0.101	0.329*	0.130	1.000	0.464**
	Sig.	0.036	0.063	0.050	0.632	0.016	0.352		0.004
	n	53	52	52	16	53	53	53	36
IL-8	r	0.138	−0.379*	0.292	0.536	0.659**	0.474**	0.464**	1.000
	Sig.	0.423	0.025	0.089	0.089	0.000	0.004	0.004
	n	36	35	35	11	36	36	36	36

The clinical variables creatinine, platelet and leukocyte counts are maximum or minimum values from the course of hospital stay whereas tPA and markers of neutrophil activation are from 1st day of hospitalization. r, Spearman's rho correlation coefficient; Sig., Significance of correlation (p); n, number of patients; MPO, Myeloperoxidase; HNE, Neutrophil elastase; IL-8, Interleukin-8; tPA, Tissue plasminogen activator;

^*p < 0.05,

^**p < 0.01.