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. 2018 Sep 19;9:975. doi: 10.3389/fphar.2018.00975

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Copyright © 2018 Rodrigues, de Oliveira Freire, Carvalho, Silva, Vasconcelos, Guerra, de Sousa Cartágenes and Garcia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sections of articular cartilage with different grades of degenerative changes in OA classified using OARSI scoring system. (A) Example of the CONTROL group - Grade 0 - normal cartilage. (B) Example of PROF250 group - grade 1, indicates intact surface with slight discontinuity in surface area (arrow). (C) Example of SR250 group - grade 3, demonstrates vertical fissure in superficial layer (arrow). (D) Example of SR500 group – grade 1, with slight discontinuity in surface area (arrow). (E) Example of SAL group - grade 4, with erosion reaching mid layer. (F) Example of SAL group - grade 5, with ulceration and fissure reaching the deep layer of articular cartilage (arrow), with areas of fibrocartilaginous repair (stars).