FIG. 16.

A schema illustrating interactions of MDSC with dendritic cells in cancer. High pro-oxidant capacity of MDSC generates reactive oxygen species, and it triggers lipid oxidation and cell death. MDSC oxygenated lipids are taken up by DC where they are deposited in lipid droplets and disturb the process of antigen cross-presentation. DC, dendritic cells; MDSC, myeloid-derived suppressor cells. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars