FIG. 3.

A model of interaction of microtubule-associated-protein-1-LC3 with CL integrated into the lipid bilayer. Model of a bilayer made up of DOPC (shown as gray surface) and CL molecules are illustrated as pink spheres, with head-groups colored orange. The protein LC3 is shown at different intervals (t = 0, 30 and 50 ns). At t = 0 ns, the van-der Waal's surface of the protein is shown; at t = 30 ns, the secondary structures are shown in ribbon diagram, enclosed within the van-der-Waal's surface; and at t = 50 ns, the residues interacting with CL (R10 and R11) are highlighted in space-filling representation. The inset shows details of a single CL molecule with acyl chains in pink and the head-group in orange. The details of the LC3-CL interactions are available in Chu et al. (16). DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars