FIG. 6.

A schema illustrating protective effects of mitochondria-targeted inhibitors of cyt c driven CL oxidation. The nitroxide group of an electron scavenger, XJB-5-131, prevents the formation of O₂^• and H₂O₂. The latter is required as a source of oxidizing equivalents for the cyt c/CL catalyzed Cl oxidation. Liganding by imidazole-substituted oleic acid conjugated with a cationic TPP-group (for mitochondrial targeting) of the heme-Fe of cyt c prevents the participation of the enzymatic complex in the catalysis of CL oxidation. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars