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. 2018 Jun 9;16:45–54. doi: 10.1016/j.molmet.2018.06.006

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Body weight (A & D), tibial length (B & E) and intestinal biometry (C & F) in Gcgr^−/−:Gpbar1^−/−(A–C) and Gcgr^−/−:Glp2r^−/−(D–F) double knockout mice and their single knockout and wild-type littermates. Body weight was assessed following overnight fasting 1 week before take down which was performed under random-fed conditions. Shown are individual data points with overlapping mean ± SD (n = 11–16 mice per genotype, combined from 2 independent mouse cohorts). SB: small bowel, LB: large bowel. Panel C: ***p < 0.001 Gcgr^−/−:Gpbar1^+/+ & Gcgr^−/−:Gpbar1^−/− vs Gcgr^+/+:Gpbar1^+/+ & Gcgr^+/+:Gpbar1^−/−; +++p < 0.001 Gcgr^−/−:Gpbar1^+/+ vs Gcgr^+/+:Gpbar1^−/−; &&&p < 0.001 Gcgr^−/−:Gpbar1^−/− vs Gcgr^+/+:Gpbar1^+/+ & Gcgr^+/+:Gpbar1^−/−. Panel F: **p < 0.01 & ***p < 0.001 Gcgr^−/−:Glp2r^+/+ & Gcgr^−/−:Glp2r^−/− vs Gcgr^+/+:Glp2r^+/+ & Gcgr^+/+:Glp2r^−/−; ++p < 0.01 Gcgr^−/−:Glp2r^−/− vs Gcgr^+/+:Glp2r^+/+ & Gcgr^+/+:Glp2r^−/−; +++p < 0.001 Gcgr^−/−:Glp2r^−/− vs Gcgr^−/−:Glp2r^+/+; &&&p < 0.001 Gcgr^−/−:Glp2r^+/+ vs Gcgr^+/+:Glp2r^+/+, Gcgr^+/+:Glp2r^−/− & Gcgr^−/−:Glp2r^−/−. Statistical significance was assessed by one-way ANOVA followed by Bonferroni's multiple comparison post hoc test.