Table 4.

Factors associated with aortic aneurysm and dissection stratified by primary/secondary Sjögren’s syndrome using Cox regression

	Patients with Sjögren’s syndrome			Patients without Sjögren’s syndrome			Ratio	Adjusted HR*	95% CI	P values
	Events	PY	Incidence rate (per 105 PY)	Events	PY	Incidence rate (per 105 PY)
Total	47	55 860.08	84.14	160	253 779.88	63.05	1.335	3.642	2.527 to 5.250	<0.001
Without RA/SLE/ SS/PBC	30	36 607.55	81.95	158	248 694.36	63.53	1.290	1.753	1.108 to 9.382	0.042
With RA/SLE/ SS/PBC	17	19 252.53	88.30	2	5085.52	39.33	2.245	3.693	2.520 to 5.411	<0.001

Ratio, incidence of patients with AA/AD divided by the incidence of patients without AA/AD.

Primary Sjögren’s syndrome: Sjögren’s syndrome without SLE, RA, SS or PBC. Secondary Sjögren’s syndrome: Sjögren’s syndrome with SLE, RA, SS or PBC.

*Adjusted adjusted for age, sex, comorbidities and medications, as listed in table 3, using Cox regression.

AA, aortic aneurysm; AD, aortic dissection; PBC, primary biliary cirrhosis; PYs, person years; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, systemic sclerosis.