Table S1.
Correlations between neurosteroid serum levels, cognitive function, and quality of life in older female subjects (>35 years old, N=40)
| DHEA
|
DHEA-S
|
Pregnenolone
|
||||
|---|---|---|---|---|---|---|
| r | P-value | r | P-value | r | P-value | |
| Cognitive function (BACS) | ||||||
| Verbal memory | 0.02 | 0.904 | 0.166 | 0.307 | 0.086 | 0.599 |
| Working memory | 0.175 | 0.281 | 0.448 | 0.004a | −0.008 | 0.959 |
| Motor speed | −0.057 | 0.726 | 0.074 | 0.648 | −0.074 | 0.652 |
| Verbal fluency | −0.248 | 0.122 | 0.151 | 0.352 | 0.184 | 0.257 |
| Attention and processing speed | −0.134 | 0.411 | −0.01 | 0.949 | 0.172 | 0.288 |
| Executive function | −0.123 | 0.451 | 0.092 | 0.574 | 0.344 | 0.03a |
| Composite score of the BACS | −0.059 | 0.719 | 0.273 | 0.088 | 0.219 | 0.175 |
| Quality of life (WHOQOL-BREF) | ||||||
| Physical health | −0.018 | 0.914 | −0.065 | 0.691 | 0.044 | 0.786 |
| Psychological health | 0.1 | 0.537 | 0.172 | 0.289 | −0.007 | 0.967 |
| Social relations | −0.003 | 0.985 | 0.032 | 0.842 | 0.047 | 0.774 |
| Environment | −0.022 | 0.893 | −0.112 | 0.493 | −0.157 | 0.334 |
Notes: Data are computed using Pearson Correlation.
P<0.01.
Abbreviations: BACS, the Brief Assessment of Cognition in Schizophrenia; DHEA, dehydroepiandrosterone; DHEA-S, dehydroepiandrosterone-sulfate; WHOQOL-BREF, the brief version of the World Health Organization Quality of Life.