Table 1.
Body weight and plasmatic parameters of WT, L.G6pc−/− and K.G6pc−/− mice treated or not with fenofibrate.
| WT | L.G6pc−/− | L.G6pc−/−+ fenofibrate | WT | K.G6pc−/− | K.G6pc−/−+ fenofibrate | |
|---|---|---|---|---|---|---|
| TG (g/L) | 0.77 ± 0.05 | 0.75 ± 0.08 | 0.36 ± 0.05 *** ## |
0.86 ± 0.03 | 0.86 ± 0.02 | 0.68 ± 0.01 *** # |
| NEFA (mg/dL) | 26.2 ± 1.8 | 28.2 ± 1.9 | 18.4 ± 1.5 * ## |
27.6 ± 1 | 29.1 ± 0.9 | 21.1 ± 0.9 *** ### |
| Cholesterol (g/L) | 1.7 ± 0.2 | 1.5 ± 0.3 | 2.4 ± 0.2 ## |
1.4 ± 0.1 | 1.2 ± 0.1 | 1.4 ± 0.1 |
| Glucose (mg/dL) | 121 ± 9 | 57 ± 7 *** |
64 ± 4 *** |
149 ± 5 | 138 ± 7 | 133 ± 8 |
| Ketone bodies (nmol/L) | 0.19 ± 0.03 | 0.72 ± 0.15 * |
1.21 ± 0.25 ** |
0.65 ± 0.05 | 1.02 ± 0.06 ** | 1.49 ± 0.05 *** ## |
| Uric acid (mg/L) | 7.8 ± 1.6 | 7.9 ± 0.7 | 10.7 ± 1.6 | 8.3 ± 0.2 | 10.4 ± 0.6 * |
14.1 ± 0.6 *** ### |
| Body weight (g) | 38.7 ± 1.1 | 36.1 ± 0.9 | 29.1 ± 0.4 *** ### |
37.6 ± 1.2 | 33.5 ± 0.6 | 27.6 ± 0.6 *** ### |
WT mice were fed a STD diet and L.G6pc−/− mice were fed a STD diet ± fenofibrate during 9 months. Data were obtained from mice after 6 h of fasting and are expressed as the mean ± S.E.M. (n = 5–14). Significant differences between WT and L.G6pc−/− and between WT and K.G6pc−/− are indicated as * p < 0.05; ** p < 0.01; *** p < 0.001. Significant differences between L.G6pc−/− and fenofibrate-treated L.G6pc−/− and between K.G6pc−/− and fenofibrate-treated K.G6pc−/− are indicated as # p < 0.05; # # p < 0.01; # # # p < 0.001. Statistical test: One-way ANOVA followed by Tukey's post hoc test.