Table 2.
Pharmacokinetic model population parameter estimates of pregabalin
| Parameter | Parameter estimate | |
|---|---|---|
| Population parameters (RSE) | Bootstrap result mean [95% CI] | |
| k a (/hour) | 6.07 [42.3%] | 6.77 [2.39–15.68] |
| Lag time (hour) | 0.495 [0.39%] | 0.493 [0.47–0.50] |
| Vd/70 kg (L) | 31.1 [3.13%] | 31.1 [29.25–32.64] |
| CL/70 kg (L/hour) | 4.5 [2.53%] | 4.51 [4.30–4.75] |
| IIV (CV, shrinkage) | ||
| ω2 k a | 2.6 (353%, 8%) | 2.44 [0.79–4.30] |
| ω2 lag time | 7.09E‐5 (0.842%, 36%) | 5.55E‐4 [1.89E‐6–2.1E‐3] |
| ω2 Vd/F | 0.0101 (10.1%, 23%) | 0.009 [0.0019–0.016] |
| ω2 CL/F | 0.00672 (8.21%, 21%) | 0.00677 [0.00031–0.014] |
| Residual error (shrinkage) | ||
| σ2 proportional | 0.0146 (14%) | 0.0141 [0.008–0.020] |
95% CI, 95% confidence interval; CL, clearance; CV, % coefficient of variation; IIV, interindividual variability; RSE, relative standard error; Vd, volume of distribution.