Table 3.
Pharmacodynamic model parameter estimates of cold pressor PTT and electrical stimulation PTT
| Parameter | Cold pressor PTT | Electrical stimulation PTT | ||
|---|---|---|---|---|
| Turnover model population parameters (RSE) | Bootstrap result mean [95% CI] | Turnover model population parameters (RSE) | Bootstrap result mean [95% CI] | |
| Baseline | 16.9 seconds (16.8%) | 17.0 [12.6–22.6] | 19.1 mA (7%) | 19.2 [16.36–22.06] |
| k out | 0.39/hour (21%) | 0.39 [0.18–0.64] | 0.494/hour (24%) | 0.50 [0.28–0.77] |
| Slope over time | −0.07 seconds/hour (57.8%) | −0.08 [−0.16–0.04] | – | – |
| Slope pregabalin | 0.135 1/mg/L (16.7%) | 0.143 [0.09–0.20] | – | – |
| Effect pregabalin | – | – | 0.322 (18%) | 0.326 [0.215–0.450] |
| IIV (CV, shrinkage) | IIV (CV, shrinkage) | |||
| ω2 BOV baseline | 0.057 (24.2%, 27%) | 0.060 [0.01–0.15] | 0.122 (22%, 2%) | 0.116 [0.070–0.172] |
| ω2 baseline | 0.283 (57.2%, 2%) | 0.267 [0.056–0.50] | – | – |
| ω2 k out | 0.738 (105%, 19%) | 0.715 [0.01–2.46] | – | – |
| ω2 effect | – | – | 0.187 (70, 25%) | 0.20 [0.02–0.60] |
| Residual error (shrinkage) | Residual error (shrinkage) | |||
| σ2 proportional | 0.041 (6%) | 0.041 [0.032–0.050] | 0.0143 (6%) | 0.0144 [0.010–0.019] |
CI, confidence interval; CV, % coefficient of variation; IIV, interindividual variability; PTT, pain tolerance threshold; RSE, relative standard error.