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. 2018 Aug 9;7(9):549–561. doi: 10.1002/psp4.12320

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© 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The functional role of TNF‐α, revealed by the effect of anti‐TNF‐α antibody infliximab upon drug‐mediated apoptosis in PANC‐1 cells. Treatment groups included control (CTRL), 20 nM gemcitabine (GEM), 100 nM birinapant (BNT) and 20 nM/100 nM gemcitabine/birinapant combined (COMB) treatment for 96 hours, with (light gray bar) or without (dark gray bar) 1 μg/ml infliximab (INF). Percentage of apoptotic cells (a) measured by annexin V/7‐AAD assay in PANC‐1 cells after treatments of 96 hours, or (b) simulated based on the network model.