Fig. 1.

(a) Ribbon and space-filling (for two representative monomers) representation of the pre-pore and the membrane-inserted state, illustrating the overall swirling movement and involving a collapse of the structure. Reprinted with permission from DOI: 10.1038/nchembio.1312, Nat. Chem. Biol., 2013. (b) The aerolysin pore structure obtained from the quasipore map (left); tilted view showing the fit of the loops at the end of the trans-membrane β-barrel (asterisk), upon crossing the bilayer the tips of the β-barrel loops fold back forming a rivet (right). Reprinted with permission from DOI: 10.1038/ncomms12062, Nat. Commun., 2016. (c) Site-directed mutagenesis regulates the selectivity and sensitivity of the aerolysin pore. Reprinted with permission from DOI: 10.1021/acssensors.8b00021, ACS Sens., 2018.