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. Author manuscript; available in PMC: 2019 Jul 28.
Published in final edited form as: J Control Release. 2018 Apr 27;282:110–119. doi: 10.1016/j.jconrel.2018.04.045

Figure 3. Excipients Rescue Endosomal Escape of MK2i-NPs In Vitro.

Figure 3

A) Concentration dependent effects of excipients on the pH-dependent membrane disruptive activity of lyophilized MK2i-NP formulations. B) Galectin 8 YFP recruitment in live A7R5 cells as an in vitro assessment of endosomal disruption mediated by lyophilized MK2i-NP formulations (n = 10 cells for each sample). (* p < .05, ** p <.01, *** p < .005) C) Representative confocal fluorescence microscopy images of galectin 8 YFP recruitment in A7R5 rat cells treated with MK2i-NP formulations. NT = no treatment, Ctrl = excipient without polyplexes.