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. Author manuscript; available in PMC: 2019 Jul 28.
Published in final edited form as: J Control Release. 2018 Apr 27;282:110–119. doi: 10.1016/j.jconrel.2018.04.045

Figure 5. Lactosucrose Improves the Bioactivity of MK2i-NPs in Human Vascular Tissue.

Figure 5

A) Experimental setup for testing MK2i-NP + excipient bioactivity in an ex vivo human saphenous vein (HSV) model. B) Representative force traces of HSV relaxation before and after treatment with and without MK2i-NPs. C) Enhancement in relaxation of contracted human saphenous vein rings in response to treatment with 10−8 M sodium nitroprusside following incubation with MK2i-NP formulations at a peptide dose of 25 μM. All data were normalized to untreated samples (n = 6; * p < 0.05, ** p< 0.01, *** p < 0.005, **** p < 0.001; Lactosucrose control is treatment with 300 mM lactosucrose alone).