Table 3. Predictors of outcome and survival in multivariable regression analysis and of infarct volumes and infarct growth in linear regression analysis.
For each laboratory parameter, a separate analysis was performed and the results shown for other non-laboratory parameters are based on the model with inclusion of the first listed laboratory parameter. Hemoglobin at admission was available for 1158 patients, hemoglobin at 24h for 939 patients, and hemoglobin nadir until day 5 for 960 patients.
| Predicting factor | P | OR | 95% CI |
| mRS 0–2 | |||
| Age | < 0.001 | 0.945 | 0.932–0.958 |
| Diabetes mellitus | < 0.001 | 0.415 | 0.271–0.635 |
| NIHSS score baseline | < 0.001 | 0.865 | 0.843–0.887 |
| Time symptom onset to treatment | < 0.001 | 0.451 | 0.317–0.642 |
| sICH | < 0.001 | 0.034 | 0.007–0.164 |
| Hemoglobin baseline | 0.001 | 1.177 | 1.069–1.295 |
| Hemoglobin 24h | 0.013 | 1.150 | 1.030–1.284 |
| Hemoglobin nadir day 5 | < 0.001 | 1.279 | 1.155–1.416 |
| Hemoglobin decrease until day 5 | 0.010 | 1.193 | 1.043–1.365 |
| Erythrocytes 24h | 0.009 | 1.559 | 1.119–2.172 |
| Erythrocytes nadir day 5 | <0.001 | 2.265 | 1.668–3.076 |
| Survival | |||
| Age | < 0.001 | 0.944 | 0.929–0.960 |
| Diabetes mellitus | 0.01 | 0.490 | 0.324–0.741 |
| NIHSS score baseline | < 0.001 | 0.903 | 0.883–0.924 |
| sICH | < 0.001 | 0.080 | 0.037–0.171 |
| Hemoglobin baseline | < 0.001 | 1.194 | 1.081–1.320 |
| Hemoglobin 24h | 0.032 | 1.131 | 1.010–1.266 |
| Hemoglobin nadir day 5 | < 0.001 | 1.237 | 1.110–1.379 |
| Erythrocytes 24h | 0.002 | 1.633 | 1.189–2.244 |
| Erythrocytes nadir day 5 | <0.001 | 2.356 | 1.758–3.158 |
| Predicting factor | P | Regression coefficient | T |
| Baseline infarct volume (based on 345 patients) | |||
| Age | 0.001 | -0.017 | -3.241 |
| Male gender | 0.036 | -0.323 | -2.109 |
| Hemoglobin baseline | 0.014 | -0.109 | -2.475 |
| Final infarct volume (based on 180 patients) | |||
| Reperfusion success | 0.006 | -0.321 | -2.788 |
| Systolic BP nadir | 0.014 | 0.022 | 2.491 |
| Hemoglobin decrease until day 5 | 0.002 | -0.285 | -3.146 |
| Newly overserved anemia until day 5 | 0.023 | 0.605 | 2.300 |
| Infarct growth (based on 180 patients) | |||
| Reperfusion success | < 0.001 | -16.299 | -5.267 |
| Hemoglobin decrease until day 5 | 0.003 | -7.596 | -3.012 |
| Newly overserved anemia until day 5 | 0.022 | 16.964 | 2.308 |
| Velocity infarct growth (based on 180 patients) | |||
| Reperfusion success | < 0.001 | -5.026 | -3.979 |
| Hemoglobin decrease until day 5 | 0.001 | -3.514 | -3.414 |
| Newly observed anemia until day 5 | 0.016 | 7.368 | 2.442 |