Fig 4. Potential clinical workflow for subject specific decision-making.

The goal of this flowchart is to identify subjects benefitting from MR and additional timepoint information. Qualitatively, baseline edge-cases (BE) group includes subjects with very high or very low cognitive performance at baseline. Follow-up edge-cases (FE) group includes subjects with non-extreme cognitive performance at baseline but substantial change in performance at follow-up. And cognitively consistent (CC) group includes subjects with non-extreme cognitive performance at baseline and marginal change in performance at follow-up. The table shows the threshold values used for MMSE and ADAS-13 scales and corresponding trajectory class distribution within each group.