Table 2.
Major diagnostic tools for primary CNS GCT
| Germ Cell Tumors (GCT) | Serum/CSF tumor markers | Immunohistochemical tumor markers |
Imaging Studies | ||
|---|---|---|---|---|---|
| Germinomas | HCG, PLAP | PLAP, c-kit and OCT3/4 |
CT brain, MRI brain, MRI spine |
||
| Non-germinomatous GCT | |||||
| teratomas | |||||
| mature | - | - | |||
| immature | HCG, AFP | - | |||
| embryonal carcinomas | - | CD30 and CK AE1/3 | |||
| choriocarcinomas | HCG | HCG | |||
| yolk sac tumors | AFP | AFP | |||
| Germ Cell Tumors (GCT) | Serum/CSF tumor markers | Immunohistochemical tumor markers | Imaging Studies | ||
| Germinomas | HCG, PLAP | PLAP, c-kit and OCT3/4 |
CT brain, MRI brain, MRI spine |
||
| Non-germinomatous GCT | |||||
| teratomas | |||||
| mature | - | - | |||
| immature | HCG, AFP | - | |||
| embryonal carcinomas | - | CD30 and CK AE1/3 | |||
| choriocarcinomas | HCG | HCG | |||
| yolk sac tumors | AFP | AFP | |||
HCG=human chorionic gonadotrophic hormone, PLAP=placental alkaline phosphatase, AFP= alpha-fetoprotein