Table 1.
Baseline characteristics of HIV-infected men age 30-74
| All (N=1272) |
No CHD Event (N=1224) |
CHD Event (N=48) |
|
|---|---|---|---|
| Age (yrs) – mean+/−SD | 51.2±8.7 (1272) | 51.1±8.7 (1224) | 55.2±8.1 (48) |
| Age (yrs) – (min, max) | (30.2,73.9) | (30.2,73.9) | (34.9,72.3) |
| Race/ethnicity – % (n) | |||
| White | 60.6 (771/1272) | 60.5 (741/1224) | 62.5 (30/48) |
| Black | 19.7 (250/1272) | 19.7 (241/1224) | 18.8 (9/48) |
| Hispanic | 13.8 (176/1272) | 13.7 (168/1224) | 16.7 (8/48) |
| Other/Unknown | 5.9 (75/1272) | 6.0 (74/1224) | 2.1 (1/48) |
| Total cholesterol (mg/dL) – mean+/−SD | 179.0±45.7 (1272) | 178.9±45.6 (1224) | 182.8±47.8 (48) |
| Total cholesterol (mg/dL) categories – % (n) | |||
| < 160 | 33.8 (430/1272) | 33.5 (410/1224) | 41.7 (20/48) |
| 160-199 | 36.9 (470/1272) | 37.4 (458/1224) | 25.0 (12/48) |
| 200-239 | 20.9 (266/1272) | 21.0 (257/1224) | 18.8 (9/48) |
| 240-279 | 6.2 (79/1272) | 6.0 (74/1224) | 10.4 (5/48) |
| >= 280 | 2.1 (27/1272) | 2.0 (25/1224) | 4.2 (2/48) |
| HDL cholesterol (mg/dL) – mean+/−SD | 43.6±14.2 (1272) | 43.7±14.3 (1224) | 40.7±11.3 (48) |
| HDL cholesterol (mg/dL) categories – % (n) | |||
| < 35 | 25.9 (329/1272) | 25.6 (313/1224) | 33.3 (16/48) |
| 35-44 | 31.6 (402/1272) | 31.7 (388/1224) | 29.2 (14/48) |
| 45-49 | 14.4 (183/1272) | 14.1 (173/1224) | 20.8 (10/48) |
| 50-59 | 16.7 (212/1272) | 16.8 (206/1224) | 12.5 (6/48) |
| >= 60 | 11.5 (146/1272) | 11.8 (144/1224) | 4.2 (2/48) |
| Systolic blood pressure – mean+/−SD | 123.6±14.8 | 123.5±14.6 (1224) | 127.2±17.0 (48) |
| Treated systolic blood pressure – mean+/−SD (n) | 127.5±16.7 (370) | 127.5±16.6 (346) | 127.5±19.3 (24) |
| Untreated systolic blood pressure – mean+/−SD (n) | 122.1±13.6 (902) | 121.9±13.5 (878) | 127.0±14.8 (24) |
| Blood pressure categories – % (n) | |||
| Optimal (SBP<120, DBP<80) | 31.0 (394/1272) | 31.2 (382/1224) | 25.0 (12/48) |
| Normal (SBP<130, DBP<85) | 29.6 (377/1272) | 29.7 (363/1224) | 29.2 (14/48) |
| High Normal (SBP<140, DBP<90) | 17.0 (216/1272) | 16.8 (206/1224) | 20.8 (10/48) |
| Stage I HTN (SBP<160, DBP<100) | 17.4 (221/1272) | 17.4 (213/1224) | 16.7 (8/48) |
| Stage II-IV HTN (SBP>=160, DBP>=100) | 5.0 (64/1272) | 4.9 (60/1224) | 8.3 (4/48) |
| Antihypertensive medication – % (n) | 29.1 (370/1272) | 28.3 (346/1224) | 50.0 (24/48) |
| Smoking – % (n) | 45.4 (578/1272) | 44.9 (549/1224) | 60.4 (29/48) |
| Diabetes – % (n) | 13.5 (172/1272) | 13.0 (159/1224) | 27.1 (13/48) |
| CD4 count – median (Q1, Q3) | 457.0 (277.0,672.0) | 457 (281,672) | 348 (222,687) |
| CD4 count < 200 cells/mm3 – % (n/N) | 14.9 (176/1183) | 14.7 (168/1140) | 18.6 (8/43) |
| HIV viral load < 400 copies/mL – % (n/N) | 77.1 (804/1043) | 77.5 (778/1004) | 66.7 (26/39) |
| Log HIV viral load – median (Q1, Q3) | 4.2 (3.5, 4.7) | 4.2 (3.5, 4.7) | 4.5 (3.9, 4.9) |
| ART use – % (n) | 94.6 (1203/1272) | 94.5 (1157/1224) | 95.8 (46/48) |
| Duration follow-up (yrs) – median (Q1, Q3) | 4.4 (3.0,5.0) | 4.5 (3.1,5.0) | 1.7 (0.6,3.8) |
| 5-year hard CHD rate – % (n) | 3.8 (48) | - | - |
| 5-year hard CHD incidence rate (per 1000 PY) | 10.0 | - | - |
| 5-year ASCVD rate – % (n) | 6.1 (78) | - | - |
| 5-year ASCVD incidence rate (per 1000 PY) | 16.4 | - | - |
SD indicates standard deviation; mg, milligrams; dL, deciliter; HDL, high-density lipoprotein; SBP, systolic blood pressure; DBP, diastolic blood pressure; HTN, hypertension; Q1, quarter 1; Q3, quarter 3; ART, antiretroviral therapy; CHD, coronary heart disease; PY, person years; ASCVD, atherosclerotic cardiovascular disease.
HIV viral load is represented as the median log viral load among individuals with detectable viral loads. Hard CHD is defined as MI or coronary death. ASCVD is defined as MI, stroke, or coronary death.