Table 1.

OPN protein expression and clinicopathological factors in advanced NSCLC patients

Characteristics	Number of patients	OPN protein expression		P-valuea
		Low	High
Gender				0.432
Male	42	18	24
Female	31	13	18
Age (years)				0.417
<65	47	19	28
≥65	26	12	14
Pathologic type				0.356
SCC	39	17	22
AC	34	14	20
Smoking history				0.281
Yes	58	26	32
No	15	5	10
Differentiation				0.031b
Low	2	1	1
Moderate	55	26	29
High	16	4	12
Metastasis				0.019b
M0	32	21	11
M1	41	11	30
Response				0.038b
PR	27	12	15
SD	38	18	20
PD	8	2	6

Notes:

^aPearson chi-square test;

^bsignificant.

Abbreviations: AC, adenocarcinoma; NSCLC, non-small-cell lung cancer; PD, progressive disease; PR, partial response; SCC, squamous cell carcinoma; SD, stable disease; OPN, osteopontin.