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. 2018 Sep 19;11:6001–6021. doi: 10.2147/OTT.S171791

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Validation of hub genes in the transcriptional level.

Notes: (A) Validation of hub genes in GSE30784. The expression status of five hub genes in the turquoise module was positively correlated with the disease status, indicating they played an important role in promoting tumorigenesis. This was in accordance with the results of WGCNA. The expression status of five hub genes in the brown module was negatively correlated with the disease status, indicating they played an important role in suppressing tumorigenesis. This was in accordance with the results of WGCNA. (B) Validation of hub genes in GSE74530 and the results were the same as earlier. (C) Validation of hub genes by TCGA HNSC data in GEPIA and we obtained similar results as above. These findings indicated that our results were reliable. ^*** indicates ⩽0.001, ^**** indicates ⩽0.0001.

Abbreviations: WGCNA, weighted gene co-expression network analysis; HNSC, head and neck squamous cell carcinoma.

Validation of hub genes in the transcriptional level.

Notes: (A) Validation of hub genes in GSE30784. The expression status of five hub genes in the turquoise module was positively correlated with the disease status, indicating they played an important role in promoting tumorigenesis. This was in accordance with the results of WGCNA. The expression status of five hub genes in the brown module was negatively correlated with the disease status, indicating they played an important role in suppressing tumorigenesis. This was in accordance with the results of WGCNA. (B) Validation of hub genes in GSE74530 and the results were the same as earlier. (C) Validation of hub genes by TCGA HNSC data in GEPIA and we obtained similar results as above. These findings indicated that our results were reliable. ^*** indicates ⩽0.001, ^**** indicates ⩽0.0001.

Abbreviations: WGCNA, weighted gene co-expression network analysis; HNSC, head and neck squamous cell carcinoma.