Table S2.
KEGG pathway enrichment analysis of turquoise module and brown module
| Category | Term | Count | % | P-value |
|---|---|---|---|---|
| Upregulated genes | ||||
| KEGG | hsa04512: ECM–receptor interaction | 33 | 4.62 | 6.07E–21 |
| KEGG | hsa04510: focal adhesion | 46 | 6.43 | 9.77E–19 |
| KEGG | hsa04151: PI3K–Akt signaling pathway | 50 | 6.99 | 2.07E–12 |
| KEGG | hsa05323: rheumatoid arthritis | 24 | 3.36 | 9.34E–12 |
| KEGG | hsa05146: amoebiasis | 26 | 3.64 | 1.35E–11 |
| KEGG | hsa04974: protein digestion and absorption | 23 | 3.22 | 6.97E–11 |
| KEGG | hsa04060: cytokine–cytokine receptor interaction | 35 | 4.90 | 2.31E–09 |
| KEGG | hsa05200: pathways in cancer | 45 | 6.29 | 6.30E–08 |
| KEGG | hsa05144: malaria | 13 | 1.82 | 2.08E–06 |
| KEGG | hsa04062: chemokine signaling pathway | 26 | 3.64 | 2.09E–06 |
| Downregulated genes | ||||
| KEGG | hsa01100: metabolic pathways | 68 | 10.00 | 1.80E–06 |
| KEGG | hsa04530: tight junction | 17 | 2.50 | 5.91E–06 |
| KEGG | hsa04972: pancreatic secretion | 13 | 1.91 | 3.28E–05 |
| KEGG | hsa00982: drug metabolism – cytochrome P450 | 11 | 1.62 | 4.84E–05 |
| KEGG | hsa00340: histidine metabolism | 6 | 0.88 | 6.44E–04 |
| KEGG | hsa00590: arachidonic acid metabolism | 9 | 1.32 | 6.93E–04 |
| KEGG | hsa00350: tyrosine metabolism | 7 | 1.03 | 7.11E–04 |
| KEGG | hsa05204: chemical carcinogenesis | 10 | 1.47 | 8.98E–04 |
| KEGG | hsa00980: metabolism of xenobiotics by cytochrome P450 | 9 | 1.32 | 0.002231 |
| KEGG | hsa04670: leukocyte transendothelial migration | 11 | 1.62 | 0.004088 |
Abbreviations: KEGG, Kyoto Encyclopedia of Genes and Genomes; ECM, extracellular matrix.