Table 3.
Difference between MIME and MILE
| Variables | Number of studies | Pooled MIME | Data MILE | Data type | WMD/OR (95% CI) | Test for overall effect | Heterogeneity | Egger’s test | Favors group | |
|---|---|---|---|---|---|---|---|---|---|---|
| Age, years | 10 (n=2,598) | – | – | Continuous | 0.77 (−0.21, 1.75) | Z=1.54, P=0.12 | P=0.209 | I2=25.4% | P=0.947 | None |
| Male sex | 10 (n=2,598) | 78.7% (931/1,183) | 75.8% (1,073/1,415) | Binary | 1.13 (0.93, 1.37) | Z=1.25, P=0.21 | P=0.461 | I2=0% | P=0.760 | None |
| AJCC stage (0, I, and II) | 7 (n=1,132) | 62.8% (325/517) | 66.8% (407/615) | Binary | 0.87 (0.63, 1.22) | Z=0.80, P=0.42 | P=0.220 | I2=26.9% | P=0.460 | None |
| Operating time (minutes) | 10 (n=1,666) | – | – | Continuous | 36.49 (7.12, 65.86) | Z=2.44, P=0.01 | P=0 | I2=98.5% | P=0.008 | MILE |
| Blood loss (mL) | 9 (n=1,613) | – | – | Continuous | 16.9 (3.22, 30.58) | Z=2.42, P=0.02 | P=0 | I2=73.2% | P=0.175 | MILE |
| Transfusion | 4 (n=511) | 11.1% (34/305) | 6.8% (14/206) | Binary | 1.25 (0.29, 5.38) | Z=0.30, P=0.76 | P=0.015 | I2=71.4% | – | None |
| Lymph nodes retrieved | 7 (n=2,419) | – | – | Continuous | 3.22 (−0.95, 7.40) | Z=1.51, P=0.130 | P=0 | I2=96.7% | P=0.120 | None |
| R0 resection | 4 (n=1,687) | 97.5% (702/720) | 94.0% (909/967) | Binary | 1.34 (0.36, 5.02) | Z=0.43, P=0.67 | P=0.015 | I2=71.2% | – | None |
| Length of hospital stay (days) | 9 (n=2,439) | – | – | Continuous | 1.29 (0.27, 2.31) | Z=2.48, P=0.013 | P=0 | I2=88% | P=0.246 | MILE |
| Length of ICU stay (days) | 4 (n=1,496) | – | – | Continuous | −0.3 (−1.28, 0.67) | Z=0.61, P=0.542 | P=0.002 | I2=79.8% | – | None |
| Pulmonary | 10 (n=1,866) | 17.3% (177/1,026) | 12.0% (101/840) | Binary | 1.96 (1.28, 3.00) | Z=3.10, P=0.002 | P=0.106 | I2=37.9% | P=0.589 | MILE |
| Cardiac arrhythmia | 5 (n=824) | 7.6% (29/381) | 5.0% (22/443) | Binary | 1.20 (0.65, 2.21) | Z=0.58, P=0.56 | P=0.941 | I2=0% | – | None |
| Anastomotic leak | 13 (n=2,457) | 12.9% (131/1,292) | 5.7% (63/1,165) | Binary | 2.55 (1.40, 4.63) | Z=3.06, P=0.002 | P=0.008 | I2=55.1% | P=0.100 | MILE |
| Severe anastomotic leak | 2 (n=1,121) | 5.2% (28/542) | 4.1% (24/579) | Binary | 1.28 (0.73, 2.23) | Z=0.86, P=0.39 | P=0.841 | I2=0% | – | None |
| Vocal cord injury/palsy | 10 (n=2,553) | 9.2% (108/1,169) | 1.4% (20/1,384) | Binary | 5.62 (3.46, 9.14) | Z=6.96, P=0.0 | P=0.825 | I2=0% | P=0.017 | MILE |
| Chyle leak | 7 (n=1,000) | 2.5% (12/485) | 1.4% (7/515) | Binary | 1.42 (0.54, 3.69) | Z=0.71, P=0.48 | P=0.510 | I2=0% | P=0.779 | None |
| Stricture | 9 (n=1,682) | 8.3% (79/950) | 6.0% (44/732) | Binary | 2.07 (1.05, 4.07) | Z=2.10, P=0.04 | P=0.043 | I2=49.9% | P=0.976 | MILE |
| 30-day/in-hospital mortality | 10 (n=3,034) | 1.8% (28/1,537) | 1.0% (15/1,497) | Binary | 1.76 (0.92, 3.36) | Z=1.72, P=0.08 | P=0.758 | I2=0% | P=0.250 | None |
| 90-day mortality | 3 (n=499) | 3.7% (9/241) | 1.6% (4/258) | Binary | 2.22 (0.71, 6.98) | Z=1.36, P=0.17 | P=0.990 | I2=0.0% | – | None |
Note: “–” means no data.
Abbreviations: AJCC, American Joint Committee on Cancer; CI, confidence interval; ICU, intensive care unit; MILE, minimally invasive Ivor Lewis esophagectomy; MIME, minimally invasive McKeown esophagectomy; OR, odds ratio; WMD, weighted mean difference.