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. 2018 Sep 20;11:6071–6080. doi: 10.2147/OTT.S171216

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© 2018 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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Expression of LINK-A affects the aerobic glycolysis of NSCLC cells.

Notes: (A) Analysis of the expression correlation between LINK-A and HK II in the GEO profile database (GDS1479). (B) Expression of HK II in LINK-A-knockdown A549 and LINK-A-overexpressing NCI-H1299 cells. (C) HKII enzyme activity changes were determined in LINK-A-knockdown A549 and LINK-A-overexpressing NCI-H1299 cells. (D) Lactate production and glucose consumption were measured in LINK-A-knockdown A549 and LINK-A-overexpressing NCI-H1299 cell media. (E) Test of HK II enzyme activity in LINK-A-overexpressed-NCI-H1299 cells after 3-BrPA and HK II specific siRNA treatment. (F) Treatment with 3-BrPA and siRNA inhibit NSCLC cancer cell proliferation in cells overexpressing LINK-A. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001.

Abbreviations: LINK-A, long intergenic noncoding RNA for kinase activation; NSCLC, non-small-cell lung cancer; HK II, hexokinase II.