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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Dev Biol. 2018 Jul 7;442(1):115–126. doi: 10.1016/j.ydbio.2018.07.005

Fig. 2. Expanded OPC specification from dLGE progenitors persists up until birth in Gsx1/2 double mutants, despite recovering in Gsx2 mutants.

Fig. 2.

By E18.5, the increased oligodendroglial specification from the dLGE is beginning to recover in Gsx2 mutants, with only slightly increased PDGFRα expression in the VZ/SVZ (D, compared to A) and no difference in Olig2-positive cells (E, compared to B) within the SVZ. Accordingly, Sp8 expression is also returning to the dLGE (F, compared to C). In contrast, Gsx1/2 double mutants continue to express highly increased levels of PDGFRα (G) and 01ig2 (H), while only few scattered Sp8- positive cells remain within the dLGE (I). The number of Olig2-positive cells as well as the area of PDGFRα- and Sp8-immunostained cells within the dLGE are quantified in J-L. Data represent the mean ±SEM. *p<0.01, as determined by a one-way ANOVA followed by a Tukey HSD post-hoc test. Scale bar: I = 100μΜ